Chinese Scientists Discovered Susceptibility Genes of Esophagus Cancer

On August 23rd, 2010, world-famous academic periodical Nature Genetics published online the finding of PLCE1 and C20orf54, two susceptibility genes of esophagus cancer on human chromosome 10 and 20,which is the joint work by Professor Wang Lidong, from Xinxiang Medical University and his team of esophagus research, and Professor Zhang Xuejun, President of Anhui Medical University and his team of complex disease research. This great achievement involved over 260 experts, scholars and graduate students from 50 tumor institutes and research centers across 17 provinces of China, with the employment of genome-wide association study (GWAS) approach. It is the largest research of esophagus genome-wide study in the world, which indicates that China has played a leading role in global esophagus susceptibility gene research.
       The Key Laboratory of Dermatology of Ministry of Education of Anhui Medical University independently undertook the task of experiments and data analysis for the project. What’s more, the lab also provided for the project GWAS data of China’s Hans normal control. This project is another breakthrough the lab has made in the area of complex disease genome-wide  study after their independent GWAS research on psoriasis, systemic lupus erythematosus(SLE),leprosy and vitiligo. It is also an example of the lab’s successfully directing and associating with domestic co-researchers’ GWAS research on complex diseases.