AHMU Professor’s Research in Ion Channel Is Published in Cell Research


Recently, an article entitled “Solution structure of the voltage-gated Tim23 channel in complex with a mitochondrial presequence peptide” was published in the prestigious Cell Research (IF:20.507). The article was the fruit of the collaborative work of Prof. Shen Bing from School of Basic Medical Sciences, AHMU, Prof. Wang Junfeng and Dr. Zhou Shu from High Magnetic Field Laboratory of the Chinese Academy of Sciences. Prof. Sheng acted as one of the corresponding authors.
Tim23 is believed to recognize and translocate precursor proteins into various mitochondrial subcompartments, but the three-dimensional structure of Tim23 channel protein has not been elucidated. The analysis of its 3D structure could help identify the functionally important amino acid sites. By studying the structure of Tim23-pCoxIV complex, this research discovered several novel features. The researchers presented the three-dimensional (3D) solution structure of the yeast Tim23 channel in complex with pCoxIV in micelles as determined by high-resolution nuclear magnetic resonance (NMR), providing structural insight into the molecular mechanism of presequence translocation. Prof. Sheng Bing has been dedicated to the physiological pathological function of ion channels. This is among the latest findings in their work in ion channel and calcium ion signaling.
It’s reported that teachers from the School of Basic Medical Sciences have published four articles in international journals with the impact factor over 10. In recent years, this school has been focusing on the recruitment and development of high-level talents, and faculty building, especially the echelon construction of high-level talents, thus witnessing a steady raise in the overall level of scientific research, and contributing to the high-quality development of the university.